The aircraft, a McDonnell Douglas MD-11F built in 1991, was en route to Honolulu when witnesses saw flames erupt from its left wing moments after liftoff. The plane struggled to gain altitude before plunging into an industrial area near the airport, creating a huge explosion and sending thick black smoke across the skyline.

Louisville emergency officials confirmed that four of the victims were on the ground and not aboard the aircraft. The crash site was close to a petroleum recycling plant and an auto-parts warehouse, causing significant property damage. Authorities issued a shelter-in-place order for nearby residents while first responders battled the fire.

The National Transportation Safety Board (NTSB) and the Federal Aviation Administration (FAA) have launched a joint investigation into the crash. Preliminary reports suggest the fire may have been caused by a mechanical failure or engine problem during the climb.

UPS Airlines released a statement expressing deep sorrow for the loss of life and confirmed full cooperation with authorities. The company temporarily suspended operations at its Louisville Worldport hub, a major logistics center handling more than 400,000 packages per hour and over 300 flights daily.

Transportation experts warn that the disruption at Louisville could affect supply chains worldwide, as the hub is a key node in UPS’s global air network. Kentucky Governor Andy Beshear expressed condolences to the families of the victims and praised first responders for their quick action.

Recovery crews continue to clear debris and gather evidence, while the NTSB is expected to release a preliminary report in the coming days.